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Back Bones, Joints and Muscles Muscle Disorders

Muscle Disorders

Protein Signaling Ties Muscle Development to Bone

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January 2012

Researchers at the University of Colorado in Boulder have found that, in embryonic mice, a protein secreted by developing bone signals muscle precursor cells to help bring about a crucial stage of muscle development. During the process, called secondary myogenesis, embryonic precursor cells differentiate and fuse to form muscle mass in the animals’ limbs1. The scientists’ discovery, which involves a protein known as Indian hedgehog (Ihh), also supports the idea that tissues p...

January 2012

Researchers at the University of Colorado in Boulder have found that, in embryonic mice, a protein secreted by developing bone signals muscle precursor cells to help bring about a crucial stage of muscle development. During the...

Genetics Home Reference: Phosphoglycerate mutase deficiency

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Reviewed December 2011What is phosphoglycerate mutase deficiency?Phosphoglycerate mutase deficiency is a disorder that primarily affects muscles used for movement (skeletal muscles). Beginning in childhood or adolescence, affected individuals experience muscle aches or cramping following strenuous physical activity. Some people with this condition also have recurrent episodes of myoglobinuria. Myoglobinuria occurs when muscle tissue breaks down abnormally and releases a protein...

Research Finds Link Between Statin Use and Progressive Muscle Disease

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September 2011Research Finds Link Between Statin Use and Progressive Muscle Disease

Each year, millions of Americans take statins, drugs collectively known to lower their blood cholesterol levels. While the drugs have proven effective in reducing heart attacks and strokes, for some people these benefits come at a cost: widespread muscle pain that persists as long as the drugs are taken. New NIAMS-supported research has found that for a subset of patients, statins appear to trigger a far...

ClinicalTrials.gov: Rhabdomyolysis

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Search of: Open Studies | "Rhabdomyolysis" - List Results - ClinicalTrials.gov
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