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Acute Myeloid Leukemia

Mapping the Evolution of Cancer Cells in Leukemia

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Mapping the Evolution of Cancer Cells in LeukemiaDrs. Timothy Graubert (left) and Matthew Walter mapped the evolution of cancer cells in seven patients with myelodysplastic syndromes who later died of leukemia.

Using whole-genome sequencing, researchers have uncovered new clues to the genetic alterations underlying acute myeloid leukemia (AML) that arises in patients who were previously diagnosed with a myelodysplastic syndrome. Myelodysplastic syndromes develop when the bone marrow stops producing enough healthy cells, and some cases progress to what is known as secondary AML.

To identify genetic mutations driving this type of AML, researchers at the Washington University School of Medicine in St. Louis sequenced the genomes of abnormal...

Acute Myeloid Leukemia (AML) Treatment in Adults (Beyond the Basics)

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Acute myeloid leukemia (AML) is a type of cancer of blood and bone marrow cells. It affects a group of white blood cells called myeloid cells. Normally, myeloid and other blood cells are produced in the bone marrow (the spongy area in the middle of bones) in a carefully controlled fashion. In someone with AML, the blood cell production process is abnormal and large numbers of immature myeloid cells are produced and may be released into the blood stream...

DNA Damage from Chemo May Help Spur Leukemia's Return

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The treatment can achieve acute myeloid leukemia remission, but better options needed, experts say

THURSDAY, Jan. 12 (HealthDay News) -- The chemotherapy used to treat a form of adult leukemia sets a trap that can result in the return of the disease within years, a new study suggests.

The finding confirms the suspicions of specialists who thought chemotherapy drugs could disrupt DNA through mutations and ultimately allow tumor cells to avoid the effects of the medications.